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Carfentanil (street name W-18, brand name Widnil) is an opioid drug similar to fentanyl. It has the greatest potency of any commercially available opioid in the world, at 10,000 times the strength of morphine, 100 times more powerful than fentanyl. It is used as an elephant sedative and can also be easily absorbed through the skin, as well as inhaled, posing a huge risk to anyone who might accidentally come into contact with it. A tiny dose (equivalent to a few grains of table salt) can prove lethal.
Unlike fentanyl, carfentanil is illegal in most countries. In the UK, it is not used in medicine and is not prescribed to patients. The drug depresses the respiratory system of the user, which can be fatal. It can also cause other side effects such as itching and nausea.
INCREASING NUMBERS ARE OVERDOSING ON CARFENTANIL
Carfentanil has been implicated in a growing number of opioid related deaths in the US and in the UK.
Carfentanil powder is a powerful derivative of fentanyl, a synthetic narcotic analgesic produced from morphine. While fentanyl is about 100 times more powerful than morphine, carfentanil is 100 times more potent than fentanyl, meaning it is 10,000 times more potent than morphine. This drug is not approved for use in humans in any capacity, and it is typically found in veterinary medicine to sedate large animals, primarily elephants. In fact, the drug is so powerful that when veterinarians handle carfentanil, they use protective gear so they don’t breathe it in or absorb it through their skin.
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Carfentanil powder and Opioid Addiction
Unlike other morphine derivatives, heroin, or other opioid narcotics, carfentanil does not lead to addiction. It is too powerful for humans who have not developed a tolerance to strong narcotics like heroin or fentanyl. Even for people who have struggled with addiction to powerful narcotics, a dose the size of a grain of salt can rapidly lead to an overdose and death.
However, carfentanil has been found cutting heroin and even fentanyl sold on the streets, starting in July 2016 in Ohio, when 35 overdoses and six deaths occurred in a span of three days. Law enforcement and emergency medical personnel warn that carfentanil sold illicitly looks like other drugs found on the street, including cocaine and heroin, because it is an odorless, white powder. Carfentanil, like fentanyl, has been found cutting heroin in order to increase its potency and the heroin dealer’s supply of the substance.
While adding fentanyl to heroin has led to an epidemic of overdoses, carfentanil has led to deadly overdoses much faster. For comparison, according to Elephant Care International, the dose of carfentanil safely administered to sedate a wild adult male African elephant, which can weight over 1 ton, is only 13 mg. A dose of fentanyl, 100 times less powerful than carfentanil, that can safely be administered to a human adult is up to 100 micrograms per hour – the equivalent of 0.1 mg. The dose for the elephant is equivalent to 13,000 micrograms of carfentanil, which is about 1.3 million micrograms of fentanyl. Hence, 1,000 mg of fentanyl, the equivalent in potency of 1 mg of carfentanil, will easily kill a human.
According to an article from the Washington Post, carfentanil’s deadliness can be expressed in a few ways. First, the Buffalo Field Campaign based out of Yellowstone National Park warns that humans should not eat the meat of bison who have been sedated with carfentanil, because it can enter the human’s body and cause an overdose. Second, Russian authorities used a weaponized chemical gas based on carfentanil to end a Chechen hostage crisis in 2002 and ended up killing 170 people with one dose.
The dose used to cut heroin is typically so small that forensic chemists often have a hard time finding it. Even so, that small amount is enough to send a person into an overdose. The Ohio Attorney General website recommends that forensic technicians and chemists who must field-test heroin for fentanyl or carfentanil use protective gear to avoid harming or killing themselves.
How Does Carfentanil Affect Humans?
Because of carfentanil’s potency, the effects on the human body and brain are very rapid. Even in elephants, the sedative effects are especially rapid. According-to Elephant Care International, veterinarians must watch elephants for signs of pulmonary edema and capillary bleeding, characterized by a pink foam issuing from the elephant’s trunk, which indicates a potentially fatal rise in blood pressure. While doses administered to elephants are specifically to knock the animal unconscious, the doses are small compared to doses of much less powerful narcotics, like oxycodone or hydrocodone, given to humans to treat pain. When even a fraction of the dose given to elephants is administered to humans, onset is rapid, difficult to stop, and hard to treat.
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Carfentanil powder rapidly binds to opioid receptors in the brain, overwhelming neural chemistry and leading to overdose symptoms almost immediately. Fentanyl, for comparison, creates an intense euphoria and drowsiness when binding to the opioid receptor in the brain. These sensations are caused by elevated dopamine levels and a reduced ability for the opioid receptors to absorb this neurotransmitter due to the presence of the narcotic. These receptors also control breathing rate, which is why opioid overdoses are typically characterized by depressed, irregular, or stopped breathing.
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Physical effects of fentanyl or heroin on the body include:
- Stomach problems, including nausea and vomiting
- Confusion or cognitive difficulty
- Sedation, including “nodding off,” when a person falls asleep then wakes up repeatedly
- Respiratory depression, then arrest
- Heart rate and blood pressure changes
In contrast, the Drug Enforcement Administration issued a warning in September 2016 about carfentanil powder, which included a disclaimer that overdose symptoms could begin within minutes of exposure to the powerful narcotic. The DEA warned that a person experiencing these symptoms should seek immediate medical attention:
- Sudden drowsiness
- Slowed or depressed breathing
- Pinpoint pupils
- Clammy skin
Because these symptoms can appear very shortly after exposure to carfentanil powder, the DEA recommended that a dose of naloxone be immediately administered in order to slow down the overdose long enough for emergency medical services to arrive and treat the individual.
The DEA has already issued a warning about the dangers of fentanyl, which is a powerful opioid approved for use in humans in limited medical circumstances. Fentanyl is most often administered as a painkiller in patients with chronic pain, who have developed a tolerance to other opioids through previous use. Mixing fentanyl with heroin or other opioids increases the potency of those drugs and increases the risk of overdose and death. Now that carfentanil has hit illicit drug markets, however, more people are dying of overdoses because of the elephant tranquilizer’s potency in humans.
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